Novel and Modified Neutrophil Elastase Inhibitor Loaded in Topical Formulations for Psoriasis Management

Human neutrophil elastase (HNE) is a serine protease that degrades matrix proteins. An excess of HNE may trigger several pathological conditions, such as psoriasis. In this work, we aimed to synthesize, characterize and formulate new HNE inhibitors with a 4-oxo-β-lactam scaffold with less toxicity,...

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Bibliographische Detailangaben
Veröffentlicht in:Pharmaceutics
Hauptverfasser: Nunes, Andreia, Marto, Joana, Gonçalves, Lídia Maria, Simões, Sandra, Félix, Rita, Ascenso, Andreia, Lopes, Francisca, Ribeiro, Helena Margarida
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7238052/
https://ncbi.nlm.nih.gov/pubmed/32295247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12040358
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