A Physiology-Based Pharmacokinetic Framework to Support Drug Development and Dose Precision During Therapeutic Hypothermia in Neonates

Therapeutic hypothermia (TH) is standard treatment for neonates (≥36 weeks) with perinatal asphyxia (PA) and hypoxic–ischemic encephalopathy. TH reduces mortality and neurodevelopmental disability due to reduced metabolic rate and decreased neuronal apoptosis. Since both hypothermia and PA influence...

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Detaylı Bibliyografya
Yayımlandı:Front Pharmacol
Asıl Yazarlar: Smits, Anne, Annaert, Pieter, Van Cruchten, Steven, Allegaert, Karel
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2020
Konular:
Pharmacology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7237643/
https://ncbi.nlm.nih.gov/pubmed/32477113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00587
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