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Circadian Clocks Function in Concert with Heat Shock Organizing Protein to Modulate Mutant Huntingtin Aggregation and Toxicity

Neurodegenerative diseases commonly involve the disruption of circadian rhythms. Studies indicate that mutant Huntingtin (mHtt), the cause of Huntington’s disease (HD), disrupts circadian rhythms often before motor symptoms are evident. Yet little is known about the molecular mechanisms by which mHt...

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Bibliografiske detaljer
Udgivet i:Cell Rep
Main Authors: Xu, Fangke, Kula-Eversole, Elzbieta, Iwanaszko, Marta, Hutchison, Alan L., Dinner, Aaron, Allada, Ravi
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7237104/
https://ncbi.nlm.nih.gov/pubmed/30943415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.03.015
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