Ataxin2 functions via CrebA to mediate Huntingtin toxicity in circadian clock neurons

Disrupted circadian rhythms is a prominent and early feature of neurodegenerative diseases including Huntington’s disease (HD). In HD patients and animal models, striatal and hypothalamic neurons expressing molecular circadian clocks are targets of mutant Huntingtin (mHtt) pathogenicity. Yet how mHt...

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Bibliographic Details
Published in:PLoS Genet
Main Authors: Xu, Fangke, Kula-Eversole, Elzbieta, Iwanaszko, Marta, Lim, Chunghun, Allada, Ravi
Format: Artigo
Language:Inglês
Published: Public Library of Science 2019
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6782096/
https://ncbi.nlm.nih.gov/pubmed/31593562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008356
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