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Ataxin2 functions via CrebA to mediate Huntingtin toxicity in circadian clock neurons
Disrupted circadian rhythms is a prominent and early feature of neurodegenerative diseases including Huntington’s disease (HD). In HD patients and animal models, striatal and hypothalamic neurons expressing molecular circadian clocks are targets of mutant Huntingtin (mHtt) pathogenicity. Yet how mHt...
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| Pubblicato in: | PLoS Genet |
|---|---|
| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6782096/ https://ncbi.nlm.nih.gov/pubmed/31593562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008356 |
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