Deriving a Dose and Regimen for Anti-Glucosaminidase Antibody Passive-Immunization for Patients with Staphylococcus aureus Osteomyelitis

PURPOSE: Staphylococcus aureus osteomyelitis remains a major clinical problem. Anti-glucosaminidase (Gmd) antibodies (1C11) are efficacious in prophylactic and therapeutic murine models. Towards clinical trials, we assess the feasibility, safety, and pharmacokinetics of 1C11 passive immunization in...

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Detalhes bibliográficos
Publicado no:Eur Cell Mater
Main Authors: Lee, Charles C., Southgate, Richard, Jiao, Cindy, Gersz, Elaine, Owen, John R., Kates, Stephen L., Beck, Christopher A., Xie, Chao, Daiss, John L., Post, Virginia, Moriarty, T. Fintan, Zeiter, Stephan, Schwarz, Edward M., Muthukrishnan, Gowrishankar
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236896/
https://ncbi.nlm.nih.gov/pubmed/32003439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.22203/eCM.v039a06
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