Precision Dosing of Doxapram in Preterm Infants Using Continuous Pharmacodynamic Data and Model-Based Pharmacokinetics: An Illustrative Case Series

INTRODUCTION: Current drug dosing in preterm infants is standardized, mostly based on bodyweight. Still, covariates such as gestational and postnatal age may importantly alter pharmacokinetics and pharmacodynamics. Evaluation of drug therapy in these patients is very difficult because objective phar...

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Foilsithe in:Front Pharmacol
Main Authors: Poppe, Jarinda A., van Weteringen, Willem, Sebek, Lotte L. G., Knibbe, Catherijne A. J., Reiss, Irwin K. M., Simons, Sinno H. P., Flint, Robert B.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2020
Ábhair:
Pharmacology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236770/
https://ncbi.nlm.nih.gov/pubmed/32477133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00665
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