Precision Dosing of Doxapram in Preterm Infants Using Continuous Pharmacodynamic Data and Model-Based Pharmacokinetics: An Illustrative Case Series

INTRODUCTION: Current drug dosing in preterm infants is standardized, mostly based on bodyweight. Still, covariates such as gestational and postnatal age may importantly alter pharmacokinetics and pharmacodynamics. Evaluation of drug therapy in these patients is very difficult because objective phar...

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Publicat a:Front Pharmacol
Autors principals: Poppe, Jarinda A., van Weteringen, Willem, Sebek, Lotte L. G., Knibbe, Catherijne A. J., Reiss, Irwin K. M., Simons, Sinno H. P., Flint, Robert B.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236770/
https://ncbi.nlm.nih.gov/pubmed/32477133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00665
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