Structure-Guided Identification of DNMT3B Inhibitors

[Image: see text] Methyltransferase 3 beta (DNMT3B) inhibitors that interfere with cancer growth are emerging possibilities for treatment of melanoma. Herein we identify small molecule inhibitors of DNMT3B starting from a homology model based on a DNMT3A crystal structure. Virtual screening by docki...

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Publicat a:ACS Med Chem Lett
Autors principals: Newton, Ana S., Faver, John C., Micevic, Goran, Muthusamy, Viswanathan, Kudalkar, Shalley N., Bertoletti, Nicole, Anderson, Karen S., Bosenberg, Marcus W., Jorgensen, William L.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2020
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236258/
https://ncbi.nlm.nih.gov/pubmed/32435413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00011
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