Predictive Gene Signature for Pyrazolopyrimidine Derivative c-Src Inhibitor 10a Sensitivity in Melanoma Cells

[Image: see text] Melanoma is a highly aggressive cancer with poor prognosis. Although more than 80% of melanomas harbor an activating mutation in genes within the MAPK pathway, which are mutually exclusive, usefulness of therapies targeting MAPK pathway are impeded by innate and/or acquired resista...

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Bibliografiska uppgifter
I publikationen:ACS Med Chem Lett
Huvudupphovsmän: Kucukkaraduman, Baris, Turk, Can, Fallacara, Anna L., Isbilen, Murat, Senses, Kerem M., Ayyildiz, Zeynep O., Akbar, Muhammad W., Lotem, Michal, Botta, Maurizio, Gure, Ali O.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2020
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236227/
https://ncbi.nlm.nih.gov/pubmed/32435407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00679
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