A comparative analysis of unintegrated HIV-1 DNA measurement as a potential biomarker of the cellular reservoir in the blood of patients controlling and non-controlling viral replication

BACKGROUND: The persistence of HIV-1 in reservoir cells is one of the major obstacles to eradicating the virus in infected individuals receiving combination antiretroviral therapy (ART). HIV-1 persists in infected cells as a stable integrated genome and more labile unintegrated DNA (uDNA), which inc...

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Bibliografski detalji
Izdano u:J Transl Med
Glavni autori: Orlandi, Chiara, Canovari, Benedetta, Bozzano, Federica, Marras, Francesco, Pasquini, Zeno, Barchiesi, Francesco, De Maria, Andrea, Magnani, Mauro, Casabianca, Anna
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2020
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236182/
https://ncbi.nlm.nih.gov/pubmed/32429953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-020-02368-y
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