A comparative analysis of unintegrated HIV-1 DNA measurement as a potential biomarker of the cellular reservoir in the blood of patients controlling and non-controlling viral replication

BACKGROUND: The persistence of HIV-1 in reservoir cells is one of the major obstacles to eradicating the virus in infected individuals receiving combination antiretroviral therapy (ART). HIV-1 persists in infected cells as a stable integrated genome and more labile unintegrated DNA (uDNA), which inc...

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Publicado en:J Transl Med
Autores principales: Orlandi, Chiara, Canovari, Benedetta, Bozzano, Federica, Marras, Francesco, Pasquini, Zeno, Barchiesi, Francesco, De Maria, Andrea, Magnani, Mauro, Casabianca, Anna
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236182/
https://ncbi.nlm.nih.gov/pubmed/32429953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-020-02368-y
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