Meprin‐α (Mep1A) enhances TNF‐α secretion by mast cells and aggravates abdominal aortic aneurysms

BACKGROUND AND PURPOSE: Abdominal aorticaneurysm (AAA) rupture is mainly due to elastic lamina degradation. As a metalloendopeptidase, meprin‐α (Mep1A) critically modulates the activity of proteins and inflammatory cytokines in various diseases. Here, we sought to investigate the functional role of...

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Dettagli Bibliografici
Pubblicato in:Br J Pharmacol
Autori principali: Gao, Ran, Liu, Duan, Guo, Wenjun, Ge, Weipeng, Fan, Tianfei, Li, Bolun, Gao, Pan, Liu, Bin, Zheng, Yuehong, Wang, Jing
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
Soggetti:
Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236073/
https://ncbi.nlm.nih.gov/pubmed/32072633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15019
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