Critical Role of Mast Cell Chymase in Mouse Abdominal Aortic Aneurysm Formation

BACKGROUND: Mast cell chymase may participate in the pathogenesis of human abdominal aortic aneurysm (AAA), yet a direct contribution of this serine protease to AAA formation remains unknown. METHODS AND RESULTS: Human AAA lesions had high numbers of chymase-immunoreactive mast cells. Serum chymase...

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Hauptverfasser: Sun, Jiusong, Zhang, Jie, Lindholt, Jes S., Sukhova, Galina K., Liu, Jian, He, Aina, Åbrink, Magnus, Pejler, Gunnar, Stevens, Richard L., Thompson, Robert W., Ennis, Terri L., Gurish, Michael F., Libby, Peter, Shi, Guo-Ping
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757146/
https://ncbi.nlm.nih.gov/pubmed/19720934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.109.849679
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