Synthetic Sphingolipids with 1,2-Pyridazine Appendages Improve Antiproliferative Activity in Human Cancer Cell Lines

[Image: see text] A synthetic sphingolipid related to a ring-constrained hydroxymethyl pyrrolidine analog of FTY720 that was known to starve cancer cells to death was chemically modified to include a series of alkoxy-tethered 3,6-substituted 1,2-pyridazines. These derivatives exhibited excellent ant...

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Publicado en:ACS Med Chem Lett
Autores principales: Bachollet, Sylvestre P. J. T., Vece, Vito, McCracken, Alison N., Finicle, Brendan T., Selwan, Elizabeth, Ben Romdhane, Nadine, Dahal, Amogha, Ramirez, Cuauhtemoc, Edinger, Aimee L., Hanessian, Stephen
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2020
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236038/
https://ncbi.nlm.nih.gov/pubmed/32435371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00553
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