A Class of Potent Inhibitors of the HIV-1 Nucleocapsid Protein Based on Aminopyrrolic Scaffolds

[Image: see text] The HIV-1 nucleocapsid protein 7 (NC) is a potential target for effective antiretroviral therapy due to its central role in virus replication, mainly linked to nucleic acid (NA) chaperone activity, and low susceptibility to drug resistance. By screening a compounds library, we iden...

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Опубликовано в: :ACS Med Chem Lett
Главные авторы: Ciaco, Stefano, Humbert, Nicolas, Real, Eléonore, Boudier, Christian, Francesconi, Oscar, Roelens, Stefano, Nativi, Cristina, Seguin-Devaux, Carole, Mori, Mattia, Mély, Yves
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2020
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236033/
https://ncbi.nlm.nih.gov/pubmed/32435373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00558
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