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Two-Step Size-Exclusion Nanofiltration of Prothrombin Complex Concentrate Using Nanocellulose-Based Filter Paper

Coagulation Factor IX-rich protrhombin complex concentrate (FIX-PCC) is a therapeutic biologic product that consists of a mixture of several human plasma-derived proteins, useful for treating hemophilia B. Due to its complex composition, FIX-PCC is very challenging to bioprocess through virus removi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Biomedicines
Hauptverfasser: Manukyan, Levon, Mantas, Athanasios, Razumikhin, Mikhail, Katalevsky, Andrey, Golubev, Eugen, Mihranyan, Albert
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7235758/
https://ncbi.nlm.nih.gov/pubmed/32224972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biomedicines8040069
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