M3814, a DNA-PK Inhibitor, Modulates ABCG2-Mediated Multidrug Resistance in Lung Cancer Cells

M3814, also known as nedisertib, is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor under phase 2 clinical trials. ABCG2 is a member of the ATP-binding cassette (ABC) transporter family that is closely related to multidrug resistance (MDR) in cancer treatment. In this study, w...

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Опубликовано в: :Front Oncol
Главные авторы: Wu, Zhuo-Xun, Peng, Zheng, Yang, Yuqi, Wang, Jing-Quan, Teng, Qiu-Xu, Lei, Zi-Ning, Fu, Yi-Ge, Patel, Ketankumar, Liu, Lili, Lin, Lizhu, Zou, Chang, Chen, Zhe-Sheng
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2020
Предметы:
Oncology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7235170/
https://ncbi.nlm.nih.gov/pubmed/32477940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.00674
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