The CD153 vaccine is a senotherapeutic option for preventing the accumulation of senescent T cells in mice

Senotherapy targeting for senescent cells is designed to attenuate age-related dysfunction. Senescent T cells, defined as CD4(+) CD44(high) CD62L(low) PD-1(+) CD153(+) cells, accumulate in visceral adipose tissues (VAT) in obese individuals. Here, we show the long-lasting effect of using CD153 vacci...

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Pubblicato in:Nat Commun
Autori principali: Yoshida, Shota, Nakagami, Hironori, Hayashi, Hiroki, Ikeda, Yuka, Sun, Jiao, Tenma, Akiko, Tomioka, Hideki, Kawano, Tomohiro, Shimamura, Munehisa, Morishita, Ryuichi, Rakugi, Hiromi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7235045/
https://ncbi.nlm.nih.gov/pubmed/32424156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16347-w
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