Patient-derived oral mucosa organoids as an in vitro model for methotrexate induced toxicity in pediatric acute lymphoblastic leukemia

We have recently established a protocol to grow wildtype human oral mucosa organoids. These three-dimensional structures can be maintained in culture long-term, do not require immortalization, and recapitulate the multilayered composition of the epithelial lining of the oral mucosa. Here, we validat...

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Pubblicato in:PLoS One
Autori principali: Driehuis, E., Oosterom, N., Heil, S. G., Muller, I. B., Lin, M., Kolders, S., Jansen, G., de Jonge, R., Pieters, R., Clevers, H., van den Heuvel-Eibrink, M. M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7233536/
https://ncbi.nlm.nih.gov/pubmed/32421698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0231588
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