Inhibition of the NKp44-PCNA Immune Checkpoint Using a mAb to PCNA

Monoclonal antibody (mAb)–based blocking of the immune checkpoints involving the CTLA4-B7 and PD1-PDL1 inhibitory axes enhance T cell–based adaptive immune responses in cancer patients. We show here that antitumor responses by natural killer (NK) cells can be enhanced by a checkpoint-blocking mAb, 1...

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Publicat a:Cancer Immunol Res
Autors principals: Kundu, Kiran, Ghosh, Susmita, Sarkar, Rhitajit, Edri, Avishay, Brusilovsky, Michael, Gershoni-Yahalom, Orly, Yossef, Rami, Shemesh, Avishai, Soria, Jean-Charles, Lazar, Vladimir, Ben-Zion, Joshua, Campbell, Kerry S., Elkabets, Moshe, Porgador, Angel
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7233522/
https://ncbi.nlm.nih.gov/pubmed/31164357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-19-0023
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