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MicroRNA-146a governs fibroblast activation and joint pathology in arthritis
Synovial fibroblasts are key cells orchestrating the inflammatory response in arthritis. Here we demonstrate that loss of miR-146a, a key epigenetic regulator of the innate immune response, leads to increased joint destruction in a TNF-driven model of arthritis by specifically regulating the behavio...
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| Veröffentlicht in: | J Autoimmun |
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7233286/ https://ncbi.nlm.nih.gov/pubmed/28545737 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2017.05.006 |
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