MicroRNA-146a governs fibroblast activation and joint pathology in arthritis

Synovial fibroblasts are key cells orchestrating the inflammatory response in arthritis. Here we demonstrate that loss of miR-146a, a key epigenetic regulator of the innate immune response, leads to increased joint destruction in a TNF-driven model of arthritis by specifically regulating the behavio...

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Publicado no:J Autoimmun
Main Authors: Saferding, Victoria, Puchner, Antonia, Goncalves-Alves, Eliana, Hofmann, Melanie, Bonelli, Michael, Brunner, Julia S., Sahin, Emine, Niederreiter, Birgit, Hayer, Silvia, Kiener, Hans P., Einwallner, Elisa, Nehmar, Ramzi, Carapito, Raphael, Georgel, Philippe, Koenders, Marije I., Boldin, Mark, Schabbauer, Gernot, Kurowska-Stolarska, Mariola, Steiner, Günter, Smolen, Josef S., Redlich, Kurt, Blüml, Stephan
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7233286/
https://ncbi.nlm.nih.gov/pubmed/28545737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2017.05.006
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