Tracking Adeno-Associated Virus Capsid Evolution by High-Throughput Sequencing

Despite early successes using recombinant adeno-associated virus (rAAV) vectors in clinical gene therapy trials, limitations remain making additional advancements a necessity. Some of the challenges include variable levels of pre-existing neutralizing antibodies and poor transduction in specific tar...

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Dades bibliogràfiques
Publicat a:Hum Gene Ther
Autors principals: de Alencastro, Gustavo, Pekrun, Katja, Valdmanis, Paul, Tiffany, Matthew, Xu, Jianpeng, Kay, Mark A.
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc., publishers 2020
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7232707/
https://ncbi.nlm.nih.gov/pubmed/32024384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2019.339
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