MK2206 Enhances Cisplatin-Induced Cytotoxicity and Apoptosis in Testicular Cancer Through Akt Signaling Pathway Inhibition

OBJECTIVE: To improve conventional chemotherapeutic efficacy, it is significant to identify novel molecular markers for chemosensitivity as well as possible molecules accelerating cell-killing mechanisms. In this study, we attempted to elucidate how MK2206, an allosteric Akt inhibitor, enhances the...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Transl Oncol
Prif Awduron: Sun, Dingqi, Wang, Jinhua, Zhang, Hui, Liu, Shuai, Wei, Peng, Wang, Haoran, Xu, Zhen, Fu, Qiang, Zhang, Keqin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Neoplasia Press 2020
Pynciau:
Original article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7231864/
https://ncbi.nlm.nih.gov/pubmed/32422572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2020.100769
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