Ligand-dependent downregulation of MR1 cell surface expression

The antigen-presenting molecule MR1 presents riboflavin-based metabolites to Mucosal-Associated Invariant T (MAIT) cells. While MR1 egress to the cell surface is ligand-dependent, the ability of small-molecule ligands to impact on MR1 cellular trafficking remains unknown. Arising from an in silico s...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Salio, Mariolina, Awad, Wael, Veerapen, Natacha, Gonzalez-Lopez, Claudia, Kulicke, Corinna, Waithe, Dominic, Martens, Anne W. J., Lewinsohn, David M., Hobrath, Judith V., Cox, Liam R., Rossjohn, Jamie, Besra, Gurdyal S., Cerundolo, Vincenzo
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7229755/
https://ncbi.nlm.nih.gov/pubmed/32341160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2003136117
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