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Characterization of the coformycin biosynthetic gene cluster in Streptomyces kaniharaensis

Coformycin and pentostatin are structurally related N-nucleoside inhibitors of adenosine deaminase characterized by an unusual 1,3-diazepine nucleobase. Herein, the cof gene cluster responsible for coformycin biosynthesis is identified. Reconstitution of the coformycin biosynthetic pathway in vitro...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Ren, Daan, Ruszczycky, Mark W., Ko, Yeonjin, Wang, Shao-An, Ogasawara, Yasushi, Kim, Minje, Liu, Hung-wen
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7229688/
https://ncbi.nlm.nih.gov/pubmed/32350138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2000111117
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