Pan-cancer analysis identifies mutations in SUGP1 that recapitulate mutant SF3B1 splicing dysregulation

The gene encoding the core spliceosomal protein SF3B1 is the most frequently mutated gene encoding a splicing factor in a variety of hematologic malignancies and solid tumors. SF3B1 mutations induce use of cryptic 3′ splice sites (3′ss), and these splicing errors contribute to tumorigenesis. However...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Liu, Zhaoqi, Zhang, Jian, Sun, Yiwei, Perea-Chamblee, Tomin E., Manley, James L., Rabadan, Raul
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2020
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7229667/
https://ncbi.nlm.nih.gov/pubmed/32332164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1922622117
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