Hepatic expression of lipopolysaccharide-binding protein (Lbp) is induced by the gut microbiota through Myd88 and impairs glucose tolerance in mice independent of obesity

OBJECTIVE: Gut-derived inflammatory factors can impair glucose homeostasis, but the underlying mechanisms are not fully understood. In this study, we investigated how hepatic gene expression is regulated by gut colonization status through myeloid differentiation primary response 88 (MYD88) and how o...

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Vydáno v:Mol Metab
Hlavní autoři: Molinaro, Antonio, Koh, Ara, Wu, Hao, Schoeler, Marc, Faggi, Maria Ilaria, Carreras, Alba, Hallén, Anna, Bäckhed, Fredrik, Caesar, Robert
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2020
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7229497/
https://ncbi.nlm.nih.gov/pubmed/32305515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2020.100997
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