Suppressed expression of LDHB promotes age-related hearing loss via aerobic glycolysis

Age-dependent decrease of mitochondrial energy production and cellular redox imbalance play significant roles in age-related hearing loss (ARHL). Lactate dehydrogenase B (LDHB) is a key glycolytic enzyme that catalyzes the interconversion of pyruvate and lactate. LDH activity and isoenzyme patterns...

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Vydáno v:Cell Death Dis
Hlavní autoři: Tian, Chunjie, Kim, Yeon Ju, Hali, Sai, Choo, Oak-Sung, Lee, Jin-Sol, Jung, Seo-Kyung, Choi, Youn-Uk, Park, Chan Bae, Choung, Yun-Hoon
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7229204/
https://ncbi.nlm.nih.gov/pubmed/32415082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2577-y
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