Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation

The exopolysaccharide galactosaminogalactan (GAG) is an important virulence factor of the fungal pathogen Aspergillus fumigatus. Deletion of a gene encoding a putative deacetylase, Agd3, leads to defects in GAG deacetylation, biofilm formation, and virulence. Here, we show that Agd3 deacetylates GAG...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Bamford, Natalie C., Le Mauff, François, Van Loon, Jaime C., Ostapska, Hanna, Snarr, Brendan D., Zhang, Yongzhen, Kitova, Elena N., Klassen, John S., Codée, Jeroen D. C., Sheppard, Donald C., Howell, P. Lynne
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7229062/
https://ncbi.nlm.nih.gov/pubmed/32415073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16144-5
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