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Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden
Cancers harbor many somatic mutations and germline variants, we hypothesized that the combined effect of germline variants that alter the structure, expression, or function of protein-coding regions of cancer-biology related genes (gHFI) determines which and how many somatic mutations (sM) must occu...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7228928/ https://ncbi.nlm.nih.gov/pubmed/32415133 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16293-7 |
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