Presence of Cytotoxic Extracellular Histones in Machine Perfusate of Donation After Circulatory Death Kidneys

BACKGROUND: Extracellular histones are cytotoxic molecules that are related to cell stress and death. They have been shown to play a crucial role in multiple pathophysiologic processes like sepsis, inflammation, vascular dysfunction, and thrombosis. Their role in organ donation and graft function an...

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Detalhes bibliográficos
Publicado no:Transplantation
Main Authors: van Smaalen, Tim C., Beurskens, Daniëlle M. H., Hoogland, E. R. Pieter, Winkens, Bjorn, Christiaans, Maarten H. L., Reutelingsperger, Chris P., van Heurn, L. W. Ernest, Nicolaes, Gerry A. F.
Formato: Artigo
Idioma:Inglês
Publicado em: Wolters Kluwer 2017
Assuntos:
Original Basic Science—General
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7228581/
https://ncbi.nlm.nih.gov/pubmed/27906828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0000000000001590
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