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The transition from local to global patterns governs the differentiation of mouse blastocysts

During mammalian blastocyst development, inner cell mass (ICM) cells differentiate into epiblast (Epi) or primitive endoderm (PrE). These two fates are characterized by the expression of the transcription factors NANOG and GATA6, respectively. Here, we investigate the spatio-temporal distribution of...

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Veröffentlicht in:PLoS One
Hauptverfasser: Fischer, Sabine C., Corujo-Simon, Elena, Lilao-Garzon, Joaquin, Stelzer, Ernst H. K., Muñoz-Descalzo, Silvia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7228118/
https://ncbi.nlm.nih.gov/pubmed/32413083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0233030
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