Two forms of CX3CL1 display differential activity and rescue cognitive deficits in CX3CL1 knockout mice

BACKGROUND: Fractalkine (CX3CL1; FKN) is a chemokine expressed by neurons that mediates communication between neurons and microglia. By regulating microglial activity, CX3CL1 can mitigate the damaging effects of chronic microglial inflammation within the brain, a state that plays a major role in agi...

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Bibliografske podrobnosti
izdano v:J Neuroinflammation
Main Authors: Winter, Aimee N., Subbarayan, Meena S., Grimmig, Bethany, Weesner, Jason A., Moss, Lauren, Peters, Melinda, Weeber, Edwin, Nash, Kevin, Bickford, Paula C.
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2020
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7227354/
https://ncbi.nlm.nih.gov/pubmed/32410624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-01828-y
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