Validation of an effective implantable pump-infusion system for chronic convection-enhanced delivery of intracerebral topotecan in a large animal model

OBJECTIVE: Intracerebral convection-enhanced delivery (CED) has been limited to short durations due to a reliance on externalized catheters. Preclinical studies investigating topotecan (TPT) CED for glioma have suggested that prolonged infusion improves survival. Internalized pump-catheter systems m...

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Pubblicato in:J Neurosurg
Autori principali: D’Amico, Randy S., Neira, Justin A., Yun, Jonathan, Alexiades, Nikita G., Banu, Matei, Englander, Zachary K., Kennedy, Benjamin C., Ung, Timothy H., Rothrock, Robert J., Romanov, Alexander, Guo, Xiaotao, Zhao, Binsheng, Sonabend, Adam M., Canoll, Peter, Bruce, Jeffrey N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7227320/
https://ncbi.nlm.nih.gov/pubmed/31374547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3171/2019.3.JNS1963
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