Validation of an effective implantable pump-infusion system for chronic convection-enhanced delivery of intracerebral topotecan in a large animal model

OBJECTIVE: Intracerebral convection-enhanced delivery (CED) has been limited to short durations due to a reliance on externalized catheters. Preclinical studies investigating topotecan (TPT) CED for glioma have suggested that prolonged infusion improves survival. Internalized pump-catheter systems m...

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Detalhes bibliográficos
Publicado no:J Neurosurg
Main Authors: D’Amico, Randy S., Neira, Justin A., Yun, Jonathan, Alexiades, Nikita G., Banu, Matei, Englander, Zachary K., Kennedy, Benjamin C., Ung, Timothy H., Rothrock, Robert J., Romanov, Alexander, Guo, Xiaotao, Zhao, Binsheng, Sonabend, Adam M., Canoll, Peter, Bruce, Jeffrey N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7227320/
https://ncbi.nlm.nih.gov/pubmed/31374547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3171/2019.3.JNS1963
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