FTO Intronic SNP Strongly Influences Human Neck Adipocyte Browning Determined by Tissue and PPARγ Specific Regulation: A Transcriptome Analysis

Brown adipocytes, abundant in deep-neck (DN) area in humans, are thermogenic with anti-obesity potential. FTO pro-obesity rs1421085 T-to-C single-nucleotide polymorphism (SNP) shifts differentiation program towards white adipocytes in subcutaneous fat. Human adipose-derived stromal cells were obtain...

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Pubblicato in:Cells
Autori principali: Tóth, Beáta B., Arianti, Rini, Shaw, Abhirup, Vámos, Attila, Veréb, Zoltán, Póliska, Szilárd, Győry, Ferenc, Bacso, Zsolt, Fésüs, László, Kristóf, Endre
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7227023/
https://ncbi.nlm.nih.gov/pubmed/32316277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9040987
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