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Delayed Demyelination and Impaired Remyelination in Aged Mice in the Cuprizone Model

To unravel the failure of remyelination in multiple sclerosis (MS) and to test promising remyelinating treatments, suitable animal models like the well-established cuprizone model are required. However, this model is only standardized in young mice. This does not represent the typical age of MS pati...

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Publicado en:Cells
Main Authors: Gingele, Stefan, Henkel, Florian, Heckers, Sandra, Moellenkamp, Thiemo M., Hümmert, Martin W., Skripuletz, Thomas, Stangel, Martin, Gudi, Viktoria
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7226973/
https://ncbi.nlm.nih.gov/pubmed/32290524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9040945
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