Redox regulation of tumor suppressor PTEN in cell signaling

Phosphatase and tensin homologs deleted on chromosome 10 (PTEN) is a potent tumor suppressor and often dysregulated in cancers. Cellular PTEN activity is restrained by the oxidation of active-site cysteine by reactive oxygen species (ROS). Recovery of its enzymatic activity predominantly depends on...

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Udgivet i:Redox Biol
Main Authors: Zhang, Ying, Park, Jiyoung, Han, Seong-Jeong, Yang, Sung Yeul, Yoon, Hyun Joong, Park, Iha, Woo, Hyun Ae, Lee, Seung-Rock
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
Fag:
Review Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7226887/
https://ncbi.nlm.nih.gov/pubmed/32413744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101553
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