Flavivirus Nonstructural Protein NS5 Dysregulates HSP90 to Broadly Inhibit JAK/STAT Signaling

Pathogenic flaviviruses antagonize host cell Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling downstream of interferons α/β. Here, we show that flaviviruses inhibit JAK/STAT signaling induced by a wide range of cytokines beyond interferon, including interleukins. Th...

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Publicado en:Cells
Autores principales: Roby, Justin A., Esser-Nobis, Katharina, Dewey-Verstelle, Elyse C., Fairgrieve, Marian R., Schwerk, Johannes, Lu, Amy Y., Soveg, Frank W., Hemann, Emily A., Hatfield, Lauren D., Keller, Brian C., Shapiro, Alexander, Forero, Adriana, Stencel-Baerenwald, Jennifer E., Savan, Ram, Gale, Michael
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7226784/
https://ncbi.nlm.nih.gov/pubmed/32272626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9040899
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