ARID1A Regulates Transcription and the Epigenetic Landscape via POLE and DMAP1 While ARID1A Deficiency or Pharmacological Inhibition Sensitizes Germ Cell Tumor Cells to ATR Inhibition

Germ cell tumors (GCTs) are the most common solid malignancies found in young men. Although they generally have high cure rates, metastases, resistance to cisplatin-based therapy, and late toxicities still represent a lethal threat, arguing for the need of new therapeutic options. In a previous stud...

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發表在:Cancers (Basel)
Main Authors: Kurz, Lukas, Miklyaeva, Alissa, Skowron, Margaretha A., Overbeck, Nina, Poschmann, Gereon, Becker, Teresa, Eul, Katharina, Kurz, Thomas, Schönberger, Stefan, Calaminus, Gabriele, Stühler, Kai, Dykhuizen, Emily, Albers, Peter, Nettersheim, Daniel
格式: Artigo
語言:Inglês
出版: MDPI 2020
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7226530/
https://ncbi.nlm.nih.gov/pubmed/32272809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12040905
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