A Novel Antibody-Drug Conjugate (ADC) Delivering a DNA Mono-Alkylating Payload to Chondroitin Sulfate Proteoglycan (CSPG4)-Expressing Melanoma

Despite emerging targeted and immunotherapy treatments, no monoclonal antibodies or antibody-drug conjugates (ADCs) directly targeting tumor cells are currently approved for melanoma therapy. The tumor-associated antigen chondroitin sulphate proteoglycan 4 (CSPG4), a neural crest glycoprotein over-e...

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Veröffentlicht in:Cancers (Basel)
Hauptverfasser: Hoffmann, Ricarda M., Crescioli, Silvia, Mele, Silvia, Sachouli, Eirini, Cheung, Anthony, Chui, Connie K., Andriollo, Paolo, Jackson, Paul J. M., Lacy, Katie E., Spicer, James F., Thurston, David E., Karagiannis, Sophia N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7226475/
https://ncbi.nlm.nih.gov/pubmed/32331483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12041029
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