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Calcitonin receptor N-glycosylation enhances peptide hormone affinity by controlling receptor dynamics
The class B G protein-coupled receptor (GPCR) calcitonin receptor (CTR) is a drug target for osteoporosis and diabetes. N-glycosylation of asparagine 130 in its extracellular domain (ECD) enhances calcitonin hormone affinity with the proximal GlcNAc residue mediating this effect through an unknown m...
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| Publicado no: | J Mol Biol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7225057/ https://ncbi.nlm.nih.gov/pubmed/32035902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2020.01.028 |
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