Truncated Latrunculins as Actin Inhibitors Targeting Plasmodium falciparum Motility and Host-Cell Invasion

Polymerization of the cytosolic protein actin is critical to cell movement and host-cell invasion by the malaria parasite, Plasmodium falciparum. Any disruption to actin polymerization dynamics will render the parasite incapable of invading a host cell and thereby unable to cause infection. Here, we...

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Dades bibliogràfiques
Publicat a:J Med Chem
Autors principals: Johnson, Swapna, Rahmani, Raphaël, Drew, Damien R., Williams, Melanie J., Wilkinson, Mark, Tan, Yan Hong, Huang, Johnny X., Tonkin, Christopher J., Beeson, James G., Baum, Jake, Smith, Brian J., Baell, Jonathan B.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7224986/
https://ncbi.nlm.nih.gov/pubmed/28002959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b01109
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