The switch-like expression of heme-regulated kinase 1 mediates neuronal proteostasis following proteasome inhibition

We examined the feedback between the major protein degradation pathway, the ubiquitin-proteasome system (UPS), and protein synthesis in rat and mouse neurons. When protein degradation was inhibited, we observed a coordinate dramatic reduction in nascent protein synthesis in neuronal cell bodies and...

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Bibliographic Details
Published in:eLife
Main Authors: Alvarez-Castelao, Beatriz, tom Dieck, Susanne, Fusco, Claudia M, Donlin-Asp, Paul, Perez, Julio D, Schuman, Erin M
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2020
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7224698/
https://ncbi.nlm.nih.gov/pubmed/32329716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.52714
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