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The switch-like expression of heme-regulated kinase 1 mediates neuronal proteostasis following proteasome inhibition
We examined the feedback between the major protein degradation pathway, the ubiquitin-proteasome system (UPS), and protein synthesis in rat and mouse neurons. When protein degradation was inhibited, we observed a coordinate dramatic reduction in nascent protein synthesis in neuronal cell bodies and...
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| Yayımlandı: | eLife |
|---|---|
| Asıl Yazarlar: | , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
eLife Sciences Publications, Ltd
2020
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7224698/ https://ncbi.nlm.nih.gov/pubmed/32329716 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.52714 |
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