TRAF4 positively regulates the osteogenic differentiation of mesenchymal stem cells by acting as an E3 ubiquitin ligase to degrade Smurf2

TNF receptor-associated factor 4 (TRAF4), a member of the TRAF family, plays an important role in the embryogenesis and development of the bone system. Mesenchymal stem cells (MSCs), which are the primary origin of osteoblasts in vivo, are key cells in bone development; however, whether TRAF4 modula...

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Publicado no:Cell Death Differ
Main Authors: Li, Jinteng, Wang, Peng, Xie, Zhongyu, Wang, Shan, Cen, Shuizhong, Li, Ming, Liu, Wenjie, Tang, Su’an, Ye, Guiwen, Zheng, Guan, Su, Hongjun, Ma, Mengjun, Wu, Xiaohua, Wu, Yanfeng, Shen, Huiyong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7224386/
https://ncbi.nlm.nih.gov/pubmed/31076633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0328-3
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