TRAF4 positively regulates the osteogenic differentiation of mesenchymal stem cells by acting as an E3 ubiquitin ligase to degrade Smurf2

TNF receptor-associated factor 4 (TRAF4), a member of the TRAF family, plays an important role in the embryogenesis and development of the bone system. Mesenchymal stem cells (MSCs), which are the primary origin of osteoblasts in vivo, are key cells in bone development; however, whether TRAF4 modula...

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Pubblicato in:Cell Death Differ
Autori principali: Li, Jinteng, Wang, Peng, Xie, Zhongyu, Wang, Shan, Cen, Shuizhong, Li, Ming, Liu, Wenjie, Tang, Su’an, Ye, Guiwen, Zheng, Guan, Su, Hongjun, Ma, Mengjun, Wu, Xiaohua, Wu, Yanfeng, Shen, Huiyong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7224386/
https://ncbi.nlm.nih.gov/pubmed/31076633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0328-3
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