Regulatory T cell depletion alters the tumor microenvironment and accelerates pancreatic carcinogenesis.

Regulatory T cells (Tregs) are abundant ion human and mouse pancreatic cancer. To understand the contribution to the immunosuppressive microenvironment, we depleted Tregs in a mouse model of pancreatic cancer. Contrary to our expectations, Treg depletion failed to relieve immunosuppression, and led...

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Bibliografiske detaljer
Udgivet i:Cancer Discov
Main Authors: Zhang, Yaqing, Lazarus, Jenny, Steele, Nina G., Yan, Wei, Lee, Ho-Joon, Nwosu, Zeribe C., Halbrook, Christopher J., Menjivar, Rosa E., Kemp, Samantha B., Sirihorachai, Veerin R., Velez-Delgado, Ashley, Donahue, Katelyn, Carpenter, Eileen S., Brown, Kristee L., Irizarry-Negron, Valerie, Nevison, Anna C., Vinta, Alekya, Anderson, Michelle A., Crawford, Howard C., Lyssiotis, Costas A., Frankel, Timothy L., Bednar, Filip, Pasca di Magliano, Marina
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7224338/
https://ncbi.nlm.nih.gov/pubmed/31911451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-0958
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