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Paradoxical Pro-inflammatory Responses by Human Macrophages to an Amoebae Host-Adapted Legionella Effector

Legionella pneumophila has co-evolved with amoebae, their natural hosts. Upon transmission to humans, the bacteria proliferate within alveolar macrophages causing pneumonia. Here we show L. pneumophila injects the effector LamA, an amylase, into the cytosol of human macrophage (hMDMs) and amoebae to...

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Foilsithe in:Cell Host Microbe
Main Authors: Price, Christopher, Jones, Snake, Mihelcic, Mirna, Santic, Marina, Kwaik, Yousef Abu
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7224327/
https://ncbi.nlm.nih.gov/pubmed/32220647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2020.03.003
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