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Pretargeted delivery of PEG-coated drug carriers to breast tumors using multivalent, bispecific antibody against polyethylene glycol and HER2

Pretargeting is an increasingly explored strategy to improve nanoparticle targeting, in which pretargeting molecules that bind both selected epitopes on target cells and nanocarriers are first administered, followed by the drug-loaded nanocarriers. Bispecific antibodies (bsAb) represent a promising...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Nanomedicine
Hauptverfasser: Parker, Christina L., McSweeney, Morgan D., Lucas, Andrew T., Jacobs, Timothy M., Wadsworth, Daniel, Zamboni, William C., Lai, Samuel K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7224238/
https://ncbi.nlm.nih.gov/pubmed/31394261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2019.102076
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