Design, synthesis and evaluation of 3-hydroxypyridin-4-ones as inhibitors of catechol-O-methyltransferase

ABSTRACT: The most effective treatment of Parkinson’s disease is restoring central dopamine levels with levodopa, the metabolic precursor of dopamine. However, due to extensive peripheral metabolism by aromatic l-amino acid decarboxylase and catechol-O-methyltransferase (COMT), only a fraction of th...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Divers
Egile Nagusiak: de Beer, Johannie, Petzer, Jacobus P., Lourens, Anna C. U., Petzer, Anél
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Springer International Publishing 2020
Gaiak:
Original Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7224104/
https://ncbi.nlm.nih.gov/pubmed/32108308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11030-020-10053-x
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